Heparin Binds to Human Monocytes and Modulates Their Procoagulant Activities and Secretory Phenotypes. Effect of Histidine-Rich Glycoprotein
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چکیده
The binding of heparin to human monocytes and the monocytoid cell line U937 was characterized. Heparin binding was rapid. specific. saturable. and reversible. There was a single class of heparin binding sites. with an apparent dissociation constant of 0.19 Mmol/L and 1 .9 x 1 0 sites per cell. The binding was not dependent on the anticoagulant property of heparin. Analysis of surfaceiodinated cell lysates by heparin affinity chromatography revealed a major 1 20 Kd cell surface heparin-binding protein. Histidine-rich glycoprotein. a potent heparin antagonist found in human plasma and platelets. decreased the
منابع مشابه
Heparin binds to human monocytes and modulates their procoagulant activities and secretory phenotypes. Effects of histidine-rich glycoprotein.
The binding of heparin to human monocytes and the monocytoid cell line U937 was characterized. Heparin binding was rapid, specific, saturable, and reversible. There was a single class of heparin binding sites, with an apparent dissociation constant of 0.19 mumol/L and 1.9 x 10(6) sites per cell. The binding was not dependent on the anticoagulant property of heparin. Analysis of surface-iodinate...
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